DHEA AND YOUR CARDIOVASCULAR DISEASE RISK FACTORS DHEA
It is known as a broad-spectrum anti-aging hormone. DHEA administration has been shown to alleviate many age-related conditions and may slow aging process itself. Studies have shown DHEA mounts a triple attack against three of the most prominent risk factors of cardiovascular disease
- Endothelial dysfuration
- Metabolic syndrome
By the time you reach age 70, your DHEA levels likely to be 75 – 80 % lower than when you were at your peak. One study found that men with lowest DHEA levels were 67% more likely to die from a heart attack and 54% more likely to die from any cause.
DHEA (dehydroepiandrosterone) is a hormone produced mostly in adrenal glands. It is most abundant of all circulating steroid hormones.
A growing body of evidence indicates that maintaining youthful DHEA levels in your blood is a good way to fend off some of the most immediate threats to your longevity mainly cardiovascular disease.
Three of the main risk factors that promote cardiovascular disease are atherosclerosis (hardening of the arteries), endothelial dysfuration (poor function of the lining layer of blood vessels), metabolic syndrome (combination of central obesity, poor blood sugar control, disturbed lipids and high blood pressure).
Numerous studies have established close connection between low DHEA-S levels and arterial narrowing and other characteristics of enteral walls. Another study showed low DHEA-S levels correlated with thickness of carotid artery (main brain artery) in men and with decreased mean blood flow in carotid artery in women.
Low DHEA-S levels are also associated with risk of atrial fibrillation. The disordered, fluttering contractions of the upper chambers that can result from atherosclerosis. In arterial lining cells in culture, DHEA administration inhibited some of the first steps in the development of atherosclerosis.
They are done by suppressing markers of oxidation, reducing inflammatory signals, inhibiting the adhesion molecules that make platelets and other cells stick to artery walls to form obstructive plaques.
Another major risk factor for cardiovascular disease is endothelial dysfunction. Endothelium plays important role in heart health because it responds to changes in blood flow and pressure.
The endothelium uses nitric oxide and other molecules to signal smooth muscle in artery walls to constrict or relax in response to need.
Damage to endothelial layer occurs as oxidised fats begin to build up. Endothelial dysfunction results in poorly responsive arterial walls, which often overgrow and thicken, further limiting their suppleness.
Inflammatory changers within the vessel wall rapidly contribute to further dysfunction, loss of responsiveness and eventually to plaque formation. Studies are showing DHEA can inhibit many of threats to endothelial that can lead to cardiovascular disease.
Treating endothelial cells in culture with DHEA reduces very and earliest inflammatory changes by decreasing expression of proteins that triggers inflammation.
Metabolic syndrome is a major treat to cardiovascular heath, an accelerator of aging and cause of premature death.
The risk of dying a cardiovascular death increased by up to 200% in people with metabolic syndrome. As DHEA declines, rate of metabolic syndrome rises, since DHEA regulates most of the processes that influence metabolic health.
Laboratory studies have shown DHEA administration reduces abdominal fat and insulin resistance.
Additionally specifically in obese women (both pre and post-menopausal) 100mg per day of DHEA supplementation decreased plasma saturated fatty acids and increased level of proactive fatty acids such as omega 3 and omega 6.
DHEA appears to contribute to stronger bones in both men and women. In older women with a daily dose of DHEA also improves muscle strength and physical function. These changes help to reduce fracture by simply reducing risk of serious fall in the first place.
DHEA is a potent regulator of many processes that if uncorrected raise your risk of heart attack, stroke or other degenerative catastrophes. Studies shows people with cardiovascular disease have significantly lower levels of circulating DHEA.
DHEA is Predictor Hormone which means to say that LOW LEVELS PRECEDE DISORDERS by 10-15 years . Hence regular monitoring even among healthy adults is important . DHEA Defi is closely associated with Autoimmune Disorders.”
People with low DHEA levels die younger than those with more youthful levels. Regular supplementation with modest doses (15 – 50 mg per day) of DHEA significantly reduces main risk factors of cardiovascular disease.